Clinical Significance of Proteinuria in Kidney Disease

What is Proteinuria?

Proteinuria is a condition in which urine contains abnormal amount of protein. Proteins in the blood also perform a number of important functions. They protect the body from infection, help blood clot, and keep the right amount of fluid circulating throughout the body.
How to diagnose?
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Proteinuria can be checked out by a urine test. Due to filtration function of glomerular filtration membrane and reabsorption function of renal tubule, in normal human body, urine protein is little and the daily discharge quality is less than 150mg. Qualitative check of protein shows negative. When protein in urine increases, it can be checked out by common urine test, which is called Proteinuria. If content of urine protein is equal or more than 3.5 grams per 24 hours, it is called abundant Proteinuria. What Medicine Is Out There to Stop Progression of Protein in Urine
How does Proteinuria in kidney disease patients occur?
Proteinuria is a typical symptom of Chronic Kidney Disease. The occurrence of Proteinuria is closely related to glomerular shielding function. Glomerular capillary consists of three layer structures, endothelium layer, basement membrane layer and epithelial layer from inside to outside. As blood passes through healthy kidneys, they filter out the waste products and leave over the things needed by the body, like albumin and other proteins. Most proteins are too big to pass through the kidneys’ filters into the urine. However, proteins from the blood can leak into the urine when the filters of the kidney are damaged.
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Proteinuria occurs in both renal and nonrenal disease. Renal diseases that produce proteinuria include glomerulonephritis, nephrosis, renal vein thrombosis, malignant hypertension, polycystic kidney disease, and chronic urinary tract obstruction. Kidney disease does not always accompanied by Proteinuria. Pyelonephritis, urinary tract obstructions, kidney stones, tumors, and congenital malformations can cause severe illness without producing Proteinuria. Nonrenal causes of proteinuria include: fever and acute infection, trauma, leukemia and multiple myeloma, toxemia and preeclampsia of pregnancy, diabetes mellitus, Waldenstrom's macroglobulinemia, systemic lupus erythematosis, and poisoning from heavy metals, phenol, opiates, or other drugs.